An 8-week supplementation of KSM-66 Ashwagandha (300mg twice daily) resulted in a notable, statistically significant 16.40% increase in VO2 max (a measure of cardiorespiratory endurance) (p=0.0074).

Link: Tiwari, S., et al., (2021). Journal of ethnopharmacology.

In another 8-week study, healthy athletic adults taking KSM-66 Ashwagandha (300mg twice daily) exhibited a statistically significant 9.51% and 7.15% increase in VO2 max for males and females, respectively (p < 0.001).

Link: Verma N, et al., (2023), F1000Research 2023, 12:335.

In a 12-week trial, healthy athletic adults taking KSM-66 Ashwagandha (300mg twice daily) experienced a marked enhancement in VO2 max, with statistically significant increases of 11.8% and 13.6% on Day 56 and Day 84, respectively (p < 0.001).

Link: Choudhary, B., et al. (2015). Ayu, 36(1), 63–68.

In an 8-week study, supplementation with KSM-66 Ashwagandha (300 mg twice daily) produced statistically significant increases of 23.5% in muscle strength for bench press in males and 22.8% in females, along with a 15% increase in leg extension exercises for males and 9.9% for females, respectively (p< 0.05).

Link: Verma N, et al., (2023), F1000Research 2023, 12:335.

In another clinical study, an 8-week supplementation with KSM-66 Ashwagandha (300mg twice daily) produced statistically significant increases of 138.7% and 52% in muscle strength for the bench press and leg extension exercise, respectively (p < 0.05).

Link: Wankhede, S., et al., (2015).Journal of the International Society of Sports Nutrition

Another study showed that 8-week supplementation with KSM-66 Ashwagandha (300mg/twice daily) resulted in a significant 6.67% improvement in Total Quality Recovery scores and a 60.71% enhancement in the Fatigue domain of the Recovery Stress Questionnaire scores (p< 0.0001).

Link: Tiwari, S., et al., (2021). Journal of ethnopharmacology, 272, 113929.

In another study, an 8-week supplementation with KSM-66 Ashwagandha (300mg/twice daily) demonstrated a significant reduction in creatine kinase levels, indicating faster recovery. (p< 0.001)

Link: Verma N, et al., (2023), IJMPR, 4(5):371-381.

In an 8-week study, KSM-66 Ashwagandha supplementation (300mg/twice daily) in sleep-challenged subjects showed a 33.50% decrease in sleep onset latency and an 11.30% increase in sleep efficiency. KSM-66 Ashwagandha also resulted in a statistically significant 45.30% increase in sleep quality (p< 0.001).

Link: Langade, D., et al., (2020). Journal of Ethnopharmacology: 264:113276.

In a second study, KSM-66 Ashwagandha supplementation (300mg/twice daily) resulted in a significant 30.32% decrease in sleep onset latency and a notable 10.39% increase in sleep efficiency. Furthermore, KSM-66 Ashwagandha led to a statistically significant improvement in sleep quality (p< 0.002).

Link: Langade, D., et al (2019). Cureus, 11(9), e5797

Title: Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.

The study demonstrated that Ashwagandha root extract (600 mg/day) significantly improved immediate memory, general memory, executive function, and attention and information processing speed, compared to placebo in adults. The supplementation was well-tolerated with no adverse events reported. These findings suggest that Ashwagandha root extract is safe and effective in enhancing memory, executive function, and attention in adults.

Title: Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study

The study demonstrated that Ashwagandha root extract (600 mg/day) significantly improved episodic memory, working memory, executive function, and the accuracy of attention, mental fatigue, mood, and vigor, compared to a placebo in adults. The supplementation was well-tolerated, with only mild adverse effects comparable to the placebo group and no serious adverse events. These findings suggest that Ashwagandha root extract is safe and effective in improving memory, cognition, mood, and fatigue in adults.

Title: A clinical assessment of the pharmacological effects of Ashwagandha root extract on parent-reported functions of cognition, behavior, sleep, fatigue, and executive function in children aged 6-12 years.

The study demonstrated that Ashwagandha root extract (300 mg/day) significantly improved episodic memory, working memory, attention, executive function, and information processing speed, compared to the placebo group. The supplementation was well-tolerated, with only mild adverse effects comparable to the placebo group and no serious adverse events. These findings suggest that Ashwagandha root extract is safe and effective in enhancing children's memory, cognition, and executive function.

(Under Peer Review)

Title: Ashwagandha Root Extract in Treatment of Mild Attention Deficit Hyperactivity Disorder (ADHD) in Children Aged 5–12 Years: A Prospective, Double-Blind, Randomized, Placebo Controlled Study.

The study demonstrated that Ashwagandha root extract (300 mg/day) significantly reduced Inattention and Hyperactivity-Impulsivity domain scores, and anxiety in children. KSM-66 Ashwagandha did not show any significant effect on the hepatic and renal parameters. The supplementation was well-tolerated, with only mild adverse effects comparable to the placebo group and no serious adverse events. These findings suggest that Ashwagandha root extract is safe and effective in improving attention, and symptoms of ADHD in children.

Ashwagandha Root Extract in Treatment of Mild Attention Deficit Hyperactivity Disorder (ADHD) in Children Aged 5–12 Years: A Prospective, Double-Blind, Randomized, Placebo Controlled Study

A 12-week study of healthy males taking KSM-66 Ashwagandha (225mg, three times daily) reported a significant 17% increase in serum testosterone levels (p < 0.001).

Link: Ambiye, V. R., et al., (2013). Evidence-based complementary and alternative medicine : eCAM, 2013, 571420.

In an 8-week study in individuals undergoing resistance training, supplementation with KSM-66 Ashwagandha (300mg twice daily) was associated with a statistically significant 15.3% increase in serum testosterone levels (p < 0.05).

Link: Wankhede, S., et al., (2015).Journal of the International Society of Sports Nutrition, 12, 43.

A third study involving healthy males found that supplementing with KSM-66 Ashwagandha (300mg twice daily) for 8 weeks led to a statistically significant increase in testosterone by 16.7% (p < 0.05).

Link: Chauhan, S., et al., (2022). Health science reports, 5(4), e741.

A fourth study on KSM-66 Ashwagandha supplementation (300mg twice daily) for 8 weeks demonstrated statistically significant increases of 10.07% and 8.11% in serum total and serum-free testosterone levels, respectively, in male participants (p < 0.0001).

Link: Verma N, et al., (2023), IJMPR, 4(5):371-381.

In a fifth study, individuals supplemented with KSM-66 Ashwagandha (300mg twice daily) for 8 weeks demonstrated a statistically significant increase of 14.3% in serum testosterone levels (p < 0.05).

Link: (under peer review)